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Mercado Financeiro – Mercado Financeiro. all patients, metastatic sites were dominated by lung, liver and central nervous system metastasis. Of three of myeloma patients, two patients had died and the other one survived. Two patients in the control group died. There were no significant differences in primary tumor site, metastatic sites and number of metastasis sites between the two groups. The overall survival time of the patients with myeloma was longer than that of the control group, which is consistent with other studies.^\[[@R17],[@R18]\]^
As for the relationship between Gd-DTPA and serum MMP-9, Gd-DTPA increased the level of serum MMP-9. However, the difference was not statistically significant. This may be caused by the limited number of samples in our study.
As for the relationship between serum MMP-9 and the existence of spinal cord compression, in all patients, spinal cord compression was excluded. In patients with B-cell lymphoma, we examined the patients with active infiltration, which was defined as patients with spinal cord compression or internal iliac or suprarenal tumor. Serum MMP-9 was higher in the patients with active infiltration, but the difference was not statistically significant. This finding is similar to studies on patients with multiple myeloma. In another study of multiple myeloma patients, the concentration of serum MMP-9 in multiple myeloma patients with spinal cord compression was higher than that in patients without spinal cord compression.^\[[@R19]\]^ In another study, during the 14 weeks of follow-up, the expression of serum MMP-9 in multiple myeloma patients decreased significantly after the treatment of bortezomib.^\[[@R20]\]^ The changes of serum MMP-9 in patients with multiple myeloma after treatment are different, but the clinical symptoms of multiple myeloma are the same.
The reason why serum MMP-9 increases in patients with multiple myeloma is not clear, but several hypotheses can be put forward. The serum MMP-9 level is associated with various tumor markers, which may relate to tumorigenesis, invasion and metastasis.^\[[@R21]\]^ The tumor markers associated with the serum MMP-9 level are known
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